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BIB_136

Phase 1 ADI-PEG 20 (pegargiminase) in ASS1-deficient metastatic uveal melanoma. PMID 35466524 (2022). Direct evidence of arginine-deprivation as therapy in ASS1-negative melanoma; rationale for precautionary L-arginine supplement avoidance pending tumour ASS1 IHC. [Tasks: 13, 15] Tier: 3 Grade: B Retrieved: 2026-05-07

Evidence grade

B

Tier

3

Cited by tasks

13, 15

Identifiers

PMID:35466524

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Full extracted findings & patient-implication analysis: bibliography/BIB_136/findings.md (research corpus). This page is a short context summary — not individualised medical advice.