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BIB_375

Obstructive sleep apnea (OSA) and melanoma prognosis — Gómez-Olivas 2023 CHEST prospective multicenter study (n=443): untreated moderate OSA aHR 2.45 (95% CI 1.09–5.49) and untreated severe OSA aHR 2.96 (95% CI 1.36–6.42) for composite melanoma endpoint (recurrence + metastasis + death) vs no OSA; CPAP-adherent OSA aHR 1.66 (95% CI 0.71–3.9; NS) — excess prognostic risk abolished by CPAP adherence. Tan 2022 meta-analysis (n=5,276,451): OSA → 71% higher pooled melanoma incidence risk. He 2025 Mendelian randomisation: causal direction (OSA → cancer) confirmed. FILLS gap in TASK11 §4.4 sleep sec…

Evidence grade

B

Tier

1 (

Cited by tasks

11, 13a, 21, 24

Identifiers

PMC11311741 · DOI:10.1016/j

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Full extracted findings & patient-implication analysis: bibliography/BIB_375/findings.md (research corpus). This page is a short context summary — not individualised medical advice.