`BIB_383`

Melanoma surveillance after WLE — evidence synthesis 2025: Soyer/Janda 2025 JAMA Dermatology RCT (PMID 40136310, n=314) shows 3D total-body photography + sequential digital dermoscopy (TBP+SDDI) INCREASED excisions (5.73 vs 3.99 per person; p<0.05) but did NOT improve melanoma detection rates (67/1527 melanomas confirmed, 4.4%, no between-group difference) — NEGATIVE TRIAL; Lindsay 2025 cost-effectiveness (PMID 40136266): TBP+SDDI cost $1708 vs $763 per person over 24 months ($945 additional) with IDENTICAL QALYs (1.84 each) — NOT cost-effective. SIGN 146 (revised March 2025, Scotland's operat…

Evidence grade: A
Tier: 1 (Soyer/Janda 2025 — JAMA Dermatolo
Cited by tasks: 05, 07, 17, 24
Identifiers: DOI:10.1001/jamadermatol · PMID:40136310

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