← Evidence library

BIB_401

Polypodium leucotomos extract (PLE) — evidence-check of the cloud-loop BIB398 "ADD PLE" proposal: surrogate-endpoint photoprotection RCT data is consistent + safety excellent, but ZERO human cancer-prevention evidence. Verdict: reasonable low-cost/low-risk ADJUNCT to (never a substitute for) topical SPF + behaviour; do NOT frame as melanoma/skin-cancer prevention — same discipline as nicotinamide/vitD/aspirin.

Evidence grade

B

Tier

2 (Nestor 2015 RCT — small, industry-sponsored, JCAD; Middelkamp-Hup 2004 JAAD f

Cited by tasks

8, 12

Identifiers

PMC4345929 · DOI:10.1089/jmf · PMID:25741399

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Full extracted findings & patient-implication analysis: bibliography/BIB_401/findings.md (research corpus). This page is a short context summary — not individualised medical advice.