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BIB_411

Creatine in oncology — evidence anchor for TASK28 (patient asked to focus on creatine). Bottom line: creatine monohydrate is one of the best-evidenced, safe ergogenic supplements for muscle/strength/healthy-ageing WITH resistance training, but cancer-population RCTs have NOT shown clinical benefit, and the preclinical cancer literature is genuinely DIRECTION-MIXED (CD8 T-cell antitumour-immunity support vs Smad2/3-driven metastasis in colorectal/breast — NOT melanoma, may not translate). NO human melanoma data either way → not a melanoma treatment, not a strong reason to avoid for legitimate …

Evidence grade

B

Tier

2 (authoritative inte

Cited by tasks

11, 13, 13a, 26, 28

Identifiers

PMC12702719

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Full extracted findings & patient-implication analysis: bibliography/BIB_411/findings.md (research corpus). This page is a short context summary — not individualised medical advice.