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BIB_413

Ageing / "age reversal" ↔ cancer — evidence anchor for TASK34 (patient asked re age-reversal & cancer; family has AI/longevity interest). Bottom line: the cancer–ageing relationship is governed by ANTAGONISTIC PLEIOTROPY / the "age-reversal–age-extension (ARAE) paradox" — the very mechanisms that "rejuvenate" cells (de-differentiation, proliferation, p53 attenuation, senescence clearance) are intrinsically ONCOGENIC. "Age-reversal" interventions (partial epigenetic/Yamanaka reprogramming, senolytics, NAD⁺ boosters, telomerase) are overwhelmingly PRECLINICAL/early, carry a NAMED cancer risk, a…

Evidence grade

D

Tier

2 (peer-reviewed a

Cited by tasks

22a, 25, 26, 34

Identifiers

DOI:10.1111/acel

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Full extracted findings & patient-implication analysis: bibliography/BIB_413/findings.md (research corpus). This page is a short context summary — not individualised medical advice.