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BIB_425

CHALLENGE trial (NEJM 2025) + Irwin editorial — FIRST RCT to prove structured exercise improves cancer DFS and OS after curative-intent treatment: DFS HR 0.72 (95% CI 0.55–0.94; P=0.02), OS HR 0.63 (37% risk-of-death reduction), 5-yr DFS 80.3% vs 73.9% in colon cancer post-chemo (n=889). Landmark NEJM editorial by Irwin (Yale SPH) calls for exercise to become standard oncology care across ALL cancers. NOT melanoma-specific (colon cancer; 90% Stage III; post-chemo) — but provides the FIRST RCT-grade proof that structured exercise after cancer diagnosis causally improves survival, upgrading BIB…

Evidence grade

A

Tier

1 (CHALLEN

Cited by tasks

11, 17, 18, 21

Identifiers

PMC8381455 · DOI:10.1056/NEJMoa2502760 · PMID:39094179

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Full extracted findings & patient-implication analysis: bibliography/BIB_425/findings.md (research corpus). This page is a short context summary — not individualised medical advice.