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BIB_436

Melatonin & melanoma — the CALIBRATED "permitted for sleep, NOT for cancer" supplement entry. Fills a ZERO-coverage gap (only incidental in BIB375/OSA) and is high-plausibility for THIS patient: FCR-prone, anxious war refugee with likely situational insomnia + a wellness/longevity family that promotes melatonin. The disciplined value is calibration: unlike the cautioned cluster (high-dose antioxidants accelerate melanoma metastasis BIB126; telomerase activators BIB414; "age-reversal" tech), melatonin's melanoma-mechanistic signal is FAVOURABLE/NEUTRAL and its safety at physiologic sleep dos…

Evidence grade

C

Tier

2–3 (melanoma-specific review of preclinical models + recent skin-cancer reviews

Cited by tasks

13a, 22, 22a

Identifiers

PMC9844458

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Full extracted findings & patient-implication analysis: bibliography/BIB_436/findings.md (research corpus). This page is a short context summary — not individualised medical advice.