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BIB_438

Obesity paradox in melanoma immunotherapy + body composition → ICI outcomes: BMI 30.4 is NOT a contingency liability — fills a ZERO-coverage gap. The prior bibliography covers GLP-1/weight (BIB374/393), exercise (BIB373/417/425), BMI-at-surgery (BIB433), but NOTHING on the obesity-paradox phenomenon that directly reframes this patient's BMI 30.4 in the contingency (Stage III+/ICI) context. The counter-intuitive finding: across advanced melanoma cohorts, higher BMI is consistently associated with BETTER ICI outcomes (OS + PFS) — but the 2025 multicenter JNCI analysis (the best-powered study,…

Evidence grade

B

Tier

1 (JNCI 2025 multicenter n=1,471 primary; supported by 2023 melanoma-specific me

Cited by tasks

11, 18

Identifiers

PMC10729294 · DOI:10.1093/jnci/djaf039 · PMID:39980388

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Full extracted findings & patient-implication analysis: bibliography/BIB_438/findings.md (research corpus). This page is a short context summary — not individualised medical advice.