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BIB_450

Dietary FIBER (high intake → better anti-PD-1 outcomes) and commercial PROBIOTIC SUPPLEMENTS (signal toward WORSE ICI response) in melanoma — the patient-MODIFIABLE diet layer the corpus lacked (distinct from the 2018 microbiome-composition landmarks BIB081/082/169). Spencer 2021 Science (n=128 fiber analysis): every +5 g/day fiber → ~30% lower progression/death risk on ICB; sufficient fiber + no probiotics = best (PFS not reached vs 13 mo). Low-fiber patients were more likely obese + on antihypertensives — exactly this patient. Actionable NOW as Mediterranean/CV competing-risk lever; contingency-relevant if upstaged to ICI; probiotic-supplement counter-misinformation (wellness-family vector

Evidence grade

B

Tier

1 for the landmark (Spencer 2021 Science, cited 945, lar

Cited by tasks

10, 12, 18, 22a, 26

Identifiers

PMC8970537 · DOI:10.1126/science

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Full extracted findings & patient-implication analysis: bibliography/BIB_450/findings.md (research corpus). This page is a short context summary — not individualised medical advice.